Context: Several investigations have shown that people in an adoption situation have a higher frequency of mental problems or disorders than the general population. However, no known meta-analysis consolidates information about the association between the adoption situation and SUICIDE attempt. Objectives: We aimed to systematically evaluate the primary observational studies that quantifi ed the association between the being adopted and SUICIDE attempt. Methods: A systematic review was designed that used a logical strategy based on specifi c descriptors in Spanish, English, and Portuguese, in combination with the Boolean operators (AND, OR). The search was performed on the following databases: PubMed, Scopus, Health Virtual Library, ProQuest, EBSCOhost, PsycArticles, BioMed Central, and Sage Journal. Articles were included until December 2018. The quality of the studies was evaluated with a tool based on the STROBE criteria. Results: Six studies met the inclusion criteria. Three studies used case-control designs and the remaining three were cohort studies. Case-control studies computed 69 SUICIDE ATTEMPTS in 1, 216 adopted people compared to 436 ATTEMPTS amidst 20, 555 non-adopted people (OR = 2. 30, 95% CI 1. 24-4. 28, I = 61%). Cohort studies computed 536 SUICIDE ATTEMPTS among 36, 965 people in adoption compared to 15, 112 ATTEMPTS in 3, 118, 069 non-adopted people (RR = 2. 99, 95% CI 2. 54-3. 53, I 2 = 73%). Conclusions: The adoption situation can increase SUICIDE ATTEMPTS; it predicts at least two times more cases of SUICIDE ATTEMPTS among adopted people than in the general population.